Linking Value to Surfaces with OptoDex®

Maintaining the bioactivity of surface immobilized biomolecules still represents a major challenge and is often key to the success of innovative bioanalytical and healthcare products. Arrayon’s photolinker polymers, branded as OptoDex®, offer elegant and adequate solutions to avoid denaturation due to immobilization and drying stress, thus keeping the biomolecules „alive“ and reconstitutable.

OptoDex® is extremely versatile: upon activation by light or temperature, OptoDex® binds to any type of material and enables reliable immobilization of proteins, polysaccharides and nucleic acids onto glass, plastic, metaloxides and a variety of other materials, including natural and synthetic fibers.

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Moreover, OptoDex® passivates surfaces by suppressing unwanted, non-specific molecular- or cell-surface interactions. By now, Arrayon has successfully bonded more than 100 different biomolecules to surfaces including antibodies, enzymes, vaccines, allergens, polysaccharides, growth factors and receptors.

IncaArray is a bioanalytical platform combining the advantages of our OptoDex® technology with microarray formats and microfluidics. Using only minute amounts of reagents and analyte, IncaArray offers a unique way to robust, fast and cost efficient immuoassays.

State-of-the-art biomolecule bonding to surfaces usually takes place in liquid phase and is followed by drying, preferably with saccharides added (Bond-And-Dry). With OptoDex®, however, biomolecules are covalently bonded to surface in complete dry state. The bonding reaction occurs in one single step without forming side products except nitrogen. Furthermore, this unique “Dry-And-Bond” procedure, in presence of dextran-based OptoDex®, abolishes denaturation stress on the bio-molecules during drying and bonding. As a consequence, astounding preservation of the molecule’s biological function is obtained. Products with OptoDex® dry state bonding are therefore extremely durable and have long shelf lives.